human protein atlas v23 Search Results


recombinant dna pcdna3 smac1 60 mcherry gift  (Addgene inc)
91
Addgene inc recombinant dna pcdna3 smac1 60 mcherry gift
Recombinant Dna Pcdna3 Smac1 60 Mcherry Gift, supplied by Addgene inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pmc08901441__mmc2-259-88-98?v=Addgene+inc
Average 91 stars, based on 1 article reviews
recombinant dna pcdna3 smac1 60 mcherry gift - by Bioz Stars, 2026-08
91/100 stars
  Buy from Supplier
human protein atlas v23 0  (Human Protein Atlas)
86
Human Protein Atlas human protein atlas v23 0
Human Protein Atlas V23 0, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pm41885088-329-1-1?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
human protein atlas v23 0 - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
hpa single cell dataset  (Human Protein Atlas)
86
Human Protein Atlas hpa single cell dataset
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Hpa Single Cell Dataset, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/med_rxiv__64898__2026__01__31__26345244-248-77-74?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
hpa single cell dataset - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
transcriptomic profiling  (Human Protein Atlas)
86
Human Protein Atlas transcriptomic profiling
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Transcriptomic Profiling, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pmc12598525-89-0-2?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
transcriptomic profiling - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
rna tissue hpa  (Human Protein Atlas)
86
Human Protein Atlas rna tissue hpa
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Rna Tissue Hpa, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/bio_rxiv__2025__09__15__676184-47-17-3?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
rna tissue hpa - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
tpm normalized counts  (Human Protein Atlas)
86
Human Protein Atlas tpm normalized counts
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Tpm Normalized Counts, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pm41102163-344-0-16?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
tpm normalized counts - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
prostate cancer cell lines  (Human Protein Atlas)
86
Human Protein Atlas prostate cancer cell lines
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Prostate Cancer Cell Lines, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pmc12531332-361-4-15?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
prostate cancer cell lines - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
immune cells  (Human Protein Atlas)
86
Human Protein Atlas immune cells
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Immune Cells, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pm41512030-60-10-14?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
immune cells - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
transcriptome data  (Human Protein Atlas)
86
Human Protein Atlas transcriptome data
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Transcriptome Data, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pm41421549-469-0-4?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
transcriptome data - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
gnaz gαz  (Human Protein Atlas)
86
Human Protein Atlas gnaz gαz
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Gnaz Gαz, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pmc11968146-463-23-18?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
gnaz gαz - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
oprk1 κor  (Human Protein Atlas)
86
Human Protein Atlas oprk1 κor
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Oprk1 κor, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pmc11968146-463-21-18?v=Human+Protein+Atlas
Average 86 stars, based on 1 article reviews
oprk1 κor - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier
human klk5 kallikrein 5 elisa kit picokine  (Boster Bio)
91
Boster Bio human klk5 kallikrein 5 elisa kit picokine
(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas <t>(HPA)</t> <t>single-cell</t> RNA-seq dataset <t>(v23).</t> Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.
Human Klk5 Kallikrein 5 Elisa Kit Picokine, supplied by Boster Bio, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+protein+atlas+v23/pmc09530879-58-22-27?v=Boster+Bio
Average 91 stars, based on 1 article reviews
human klk5 kallikrein 5 elisa kit picokine - by Bioz Stars, 2026-08
91/100 stars
  Buy from Supplier

Image Search Results


(a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas (HPA) single-cell RNA-seq dataset (v23). Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.

Journal: medRxiv

Article Title: THR-6E: A Six-Gene Cell-of-Origin Signature Stratifies Risk and Predicts Systemic Therapy Response in ER+/HER2− Breast Cancer

doi: 10.64898/2026.01.31.26345244

Figure Lengend Snippet: (a) THR-6E and MKI67 (Ki67) expression across normal breast glandular epithelial cell subsets in the Human Protein Atlas (HPA) single-cell RNA-seq dataset (v23). Values are reported as normalized transcripts per million (nTPM) for the indicated epithelial clusters (C1, C4, C9, C11, C16, C17, C21). (b) Fraction of cells expressing ESR1 (ER), AR, and VDR across the same glandular breast epithelial clusters in HPA (v23). Percent expression denotes the proportion of cells within each cluster with detectable transcript. (c) Gene–gene correlation matrices for THR-6E and PAM50 gene sets in normal breast tissue (top) and breast tumors (bottom) from TNMplot. Colors represent Spearman correlation coefficients (−1 to 1). (d) Genomic alteration frequencies for THR-6E, Oncotype DX, and PAM-50 gene sets in breast cancer using combined TCGA-BRCA and METABRIC cohorts (total n=3,593). Alterations include mutations and copy-number changes as reported by cBioPortal. THR-6E genes show low alteration frequency (mean 1.1%), whereas Oncotype DX and PAM-50 include multiple genes with recurrent copy-number gains (15–20% in queried genes). (e) Protein–protein interaction network of THR-6E with ESR1, AR, and VDR generated using STRING (v12.0) with k-means clustering. Orange arrows indicate literature-supported regulatory relationships overlaid on the STRING network. (f) CancerGeneNet (SIGNOR) network linking THR-6E genes to cancer-associated phenotypes. Query proteins are shown in yellow, first neighbors in green; protein families are shown as white circles and protein complexes as blue clover symbols. Solid edges denote direct interactions and dashed edges denote indirect interactions; blue arrows indicate up-regulation and red T-bars indicate down-regulation.

Article Snippet: THR-6E expression in normal tissues is breast-enriched and maps to specific glandular epithelial cell subsets. (a) Tissue-level expression of ESR1 (ER), AR, and VDR and the six THR-6E gene products (KIF4A, KIF2C, CDC20, FAM64A/PIMREG, TPX2, and LMNB2) across normal human tissues, queried in ProteomicsDB. (b) Cluster-level expression of THR-6E, ESR1 (ER), AR, VDR, and MKI67 (Ki67) across normal human breast glandular epithelial cell clusters (C1, C4, C9, C11, C16, C17, C20, C21) from the Human Protein Atlas (HPA) single-cell dataset (v23).

Techniques: Expressing, Single Cell, RNA Sequencing, Generated